STUDIES IN EXPERIMENTAL DIABETES AFTER PANCREATECTOMY

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Management of secondary diabetes mellitus after total pancreatectomy in infancy

We report five children who required total pancreatectomy in the neonatal period for life threatening hypoglycaemia. Subsequent diabetes was managed with once daily subcutaneous insulin, oral pancreatic extract, and a controlled carbohydrate diet. Daily home blood glucose profiles in four of these children were different from those of 14 C-peptide negative children with type 1 insulin dependent...

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Management of secondary diabetes mellitus after total pancreatectomy in infancy.

We report five children who required total pancreatectomy in the neonatal period for life threatening hypoglycaemia. Subsequent diabetes was managed with once daily subcutaneous insulin, oral pancreatic extract, and a controlled carbohydrate diet. Daily home blood glucose profiles in four of these children were different from those of 14 C-peptide negative children with type 1 insulin dependent...

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Experimental Studies on Diabetes

1. The injurious effects of excessive carbohydrate diet are demonstrable in partially depancreatized dogs, in the same manner as in human patients. With severe diabetes there is rapid progress of emaciation and weakness and early death. 2. With milder diabetes, there is frequently a transitional state following operation, when the fate depends on the diet. If the tolerance is spared for a time,...

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Studies on Experimental Diabetes

Experimental diabetes has been characterized as a metabolic state involving both overproduction and underutilization of glucose. Although these changes have been recognized for many years, the specific biochemical alterations resulting in increased hepatic glucose production have not been adequately described. The adrenal cortical steroids are known, however, to have an important role in the re...

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Pancreatic Diabetes after Distal Pancreatectomy: Incidence Rate and Risk Factors

PURPOSE Pancreatectomy can impair production of endocrine and exocrine hormones. In this study, we evaluated: 1) the incidence rate of diabetes in patients undergoing distal pancreatectomy; 2) the correlation between the occurrence of pancreatic diabetes and the extent of the resected pancreas; and 3) factors associated with the development of pancreatic diabetes. METHODS We retrospectively r...

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ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 1916

ISSN: 0021-9258

DOI: 10.1016/s0021-9258(18)87570-6